The TC221, TC225 and TC227 are full-frame charge-coupled device (CCD) image sensors designed specifically for medical and industrial applications where ruggedness and small size are required. The image-area diagonal measures 1.3 mm for the TC227, 2.4 mm for the TC221, and 3.63 mm for the TC225. The image sensors contain, in addition to dark reference pixels, 190, 285, and 102 active lines with 190, 285, and 102 active pixels per line, respectively. The antiblooming feature is activated by supplying clock pulses to the antiblooming gate, an integral part of each image-sensing element. The charge is converted to signal voltage at 9.5 V per electron by a high-performance structure with built-in automatic reset and a voltage-reference generator. The signal is further buffered by a low-noise two-stage source-follower amplifier to provide high output-drive capability.