The LMP8358 is a precision programmable-gain instrumentation amplifier in National's LMP precision amplifier family. Its gain can be programmed to 10, 20, 50, 100, 200, 500, or 1000 through an SPI-compatible serial interface or through a parallel interface. Alternatively, its gain can be set to an arbitrary value using two external resistors. The LMP8358 uses patented techniques to measure and continuously correct its input offset voltage, eliminating offset drift over time and temperature and the effect of 1/f noise. Its ground-sensing CMOS input features a high CMRR and low input bias currents. It is capable of sensing differential input voltages in a commonmode range that extends from 100mV below the negative supply to 1.4V below the positive supply, making it an ideal solution for interfacing with ground-referenced sensors, supply-referenced sensor bridges, and any other application requiring precision and long-term stability. Additionally, the LMP8358 includes fault detection circuitry to detect open and shorted inputs and deteriorating connections to the signal source. Other features that make the LMP8358 a versatile solution for many applications are its rail-to-rail output, low input voltage noise and high gain-bandwidth product.