The LTC2480 includes on-chip programmable gain, a temperature sensor and an oscillator. The LTC2480 can be configured to provide a programmable gain from 1 to 256 in 8 steps, measure an external signal or internal temperature sensor and reject line frequencies. 50Hz, 60Hz or simultaneous 50Hz/60Hz line frequency rejection can be selected as well as a 2x speed-up mode. The LTC2480 allows a wide common mode input range (0V to VCC) independent of the reference voltage. The reference can be as low as 100mV or can be tied directly to VCC. The LTC2480 includes an on-chip trimmed oscillator eliminating the need for external crystals or oscillators. Absolute accuracy and low drift are automatically maintained through continuous, transparent, offset and full-scale calibration.