The ADS1250 is a precision, wide dynamic range, delta-sigma, analog-to-digital converter with 20-bit resolution operating from a single +5V supply. The delta-sigma architecture is used for wide dynamic range and to guarantee 20 bits of no missing code performance. An effective resolution of 18 bits (2.8ppm of rms noise) is achieved for conversion rates up to 25kHz. The dynamic range of the converter is further increased by providing a low-noise Programmable Gain Amplifier (PGA) with gain stages of 1, 2, 4, or 8 for low level input signals. The ADS1250 is designed for high-resolution measurement applications in cardiac diagnostics, smart transmitters, industrial process control, weigh scales, chromatography and portable instrumentation. The converter includes a flexible synchronous serial interface and offers a three-wire control mode for low-cost isolation.