The AD8279 consists of two general-purpose difference amplifiers intended for precision signal conditioning in power critical applications that require both high performance and low power. The AD8279 provides exceptional common-mode rejection ratio (80 dB) and high bandwidth while amplifying signals well beyond the supply rails. The on-chip resistors are laser-trimmed for excellent gain accuracy and high CMRR. They also have extremely low gain drift vs. temperature. The common-mode range of the amplifiers extend to almost triple the supply voltage (for G = ), making them ideal for single-supply applications that require a high common-mode voltage range. The internal resistors and ESD circuitry at the inputs also provide overvoltage protection to the op amp. The AD8279 can be used as difference amplifiers with G = or G = 2. It can also be connected in a high precision, single-ended configuration for non-inverting and inverting gains of -, -2, +3, +2, +1, +1, or +. The AD8279 provide an integrated precision solution that has a smaller size, lower cost, and better performance than a discrete alternative.