The AD8253 is an instrumentation amplifier with digitally programmable gains that has G input impedance, low output noise, and low distortion making it suitable for interfacing with sensors and driving high sample rate analog-to-digital converters (ADCs). It has high bandwidth of 10 MHz, low THD and fast settling time of 615 ns to 0.001%. Offset drift and gain drift are specified to 1.2 V/C and 10 ppm/C, respectively for G = 1000. In addition to its wide input common voltage range, it boasts a high common-mode rejection of 80 dB at G = 1 from dc to 50 kHz. The combination of precision dc performance coupled with high speed capabilities make the AD8253 an excellent candidate for data acquisition. Furthermore, this monolithic solution simplifies design and manufacturing, and boosts performance of instrumentation by maintaining a tight match of internal resistors and amplifiers.