The AD8227 is designed to work with a variety of signal voltages. A wide input range and rail-to-rail output allow the signal to make full use of the supply rails. Because the input range can also go below the negative supply, small signals near ground can be amplified without requiring dual supplies. The AD8227 operates on supplies ranging from 1.5 V to 18 V (2.2 V to 36 V single supply).