The AD8224 is the first single-supply junction field effect transistor (JFET) input instrumentation amplifier available in the space-saving 16-lead, 4 mmx4 mm LFCSP. It requires the same board area as a typical single instrumentation amplifier, yet doubles the channel density and offers a lower cost per channel without compromising performance. Designed to meet the needs of high performance, portable instrumentation, the AD8224 has a minimum common-mode rejection ratio (CMRR) of 86 dB at dc and a minimum CMRR of 80 dB at 5 kHz for G = 1. Maximum input bias current is 10 pA and typically remains below 300 pA over the entire industrial temperature range. Despite the JFET inputs, the AD8224 typically has a noise corner of only 10 Hz. With the proliferation of mixed-signal processing, the number of power supplies required in each system has grown.