The AD8221 is a gain programmable, high performance instrumentation amplifier that delivers the industry's highest CMRR over frequency. The CMRR of instrumentation amplifiers on the market today falls off at 200 Hz. In contrast, the AD8221 maintains a minimum CMRR of 80 dB to 10 kHz for all grades at G = 1. High CMRR over frequency allows the AD8221 to reject wideband interference and line harmonics, greatly simplifying filter requirements. Possible applications include precision data acquisition, biomedical analysis, and aerospace instrumentation.