The AD8220 is the first single-supply JFET input instrumentation amplifier available in an MSOP package. Designed to meet the needs of high performance, portable instrumentation, the AD8220 has a minimum common-mode rejection ratio (CMRR) of 86 dB at dc and a minimum CMRR of 80 dB at 5 kHz for G = 1. Maximum input bias current is 10 pA and typically remains below 300 pA over the entire industrial temperature range. Despite the JFET inputs, the AD8220 typically has a noise corner of only 10 Hz. With the proliferation of mixed-signal processing, the number of power supplies required in each system has grown. The AD8220 is designed to alleviate this problem. The AD8220 can operate on a 18 V dual supply, as well as on a single +5 V supply. Its rail-to-rail output stage maximizes dynamic range on the low voltage supplies common in portable applications. Its ability to run on a single 5 V supply eliminates the need to use higher voltage, dual supplies. The AD8220 draws a maximum of 750 A of quiescent current, making it ideal for battery-powered devices.